Glucose-related publications from our hospital

In the University Medical Center Groningen, the glucose group at the surgical ICU has worked on a number of reports on glucose control in critically ill patients:

• Vogelzang M, van der Horst IC, Nijsten MW: Hyperglycaemic index as a tool to assess glucose control: a retrospective study. Crit Care 2004;8:R122-7
  In this paper we have analyzed a large retrospective patient cohort. We found that the "hyperglycemic index" (HGI), a calculated parameter incorporating all glucose values measured during the entire length of stay, which is not erroneously lowered by hypoglycemia, correlated better with mortality than other measures of glucose control, including maximum, admission and mean morning hyperglycemia. This article is available as FREE FULL TEXT.

• Vogelzang M, Zijlstra F, Nijsten MW: Design and implementation of GRIP: a computerized glucose control system at a surgical intensive care unit. BMC Med Inform Decis Mak 2005;5:38
  This paper describes the design and implementation of the GRIP system. This article is available as FREE FULL TEXT.

• Vogelzang M, Nijboer JM, van der Horst IC, et al.: Hyperglycemia has a stronger relation with outcome in trauma patients than in other critically ill patients. J Trauma 2006;60:873-7.
  This paper describes how trauma patients have a different glucose profile when admitted to the ICU than other critically ill patients. The difference in glucose levels between survivors and non-survivors is much larger. We hypothesize that different mechanisms may play a role in trauma patients, and that intensive insulin therapy needs to be validated in this group of patients, as randomized studies have included few trauma patients.

• Vogelzang M, Zijlstra F: Glucose metabolism and acute myocardial infarction.Eur Heart J 2006;27:1264-5.
  In this editorial we describe how the true value of intensive insulin therapy in patients with acute myocardial infarction is underinvestigated, as no tight glycemic control was achieved in these patients.

• van der Horst IC, Nijsten MW, Vogelzang M, Zijlstra F: Persistent hyperglycemia is an independent predictor of outcome in acute myocardial infarction. Cardiovasc Diabetol 2007;6:2.
  This paper describes how persistent hyperglycemia, similar to HGI, correlates better with outcome than single-point measurements of glucose. This paper is available as FREE FULL TEXT.

• Vogelzang M, Ligtenberg JJ: Practical aspects of implementing tight glucose control in the ICU. Curr Opin Clin Nutr Metab Care 2007;10:178-80.
  In this paper we briefly review the steps needed to implement tight glucose control in the intensive care unit.

• Corstjens AM, Ligtenberg JJ, van der Horst IC, et al.: Accuracy and feasibility of point-of-care and continuous blood glucose analysis in critically ill ICU patients. Crit Care 2006;10:R135.
• Ligtenberg JJ, Meertens JH, Monteban-Kooistra WE, et al.: Multicentric, randomized, controlled trial to evaluate blood glucose control by the model predictive control algorithm versus routine glucose management protocols in intensive care unit patients: Response to Plank et al. Diabetes Care 2006;29:1987.
• Corstjens AM, van der Horst IC, Zijlstra JG, et al.: Hyperglycaemia in critically ill patients: marker or mediator of mortality? Crit Care 2006;10:216.
• Ligtenberg JJ, Meijering S, Stienstra Y, et al.: Mean glucose level is not an independent risk factor for mortality in mixed ICU patients. Intensive Care Med 2006;32:435-8.
• Meijering S, Corstjens AM, Tulleken JE, et al. Towards a feasible algorithm for tight glycaemic control in critically ill patients: a systematic review of the literature. Crit Care 2006;10:R19.
• Ligtenberg JJ, Meijering S, Stienstra Y, et al.: Relationship of baseline glucose and mortality during medical critical illness? Chest 2005;127:2283